Ok, so, assuming you aren't asking because you've been experimenting with LSD and have lost your mind, I'll try to break it down for you in my own opinion. Forgive me for the western-centrist thought patterns.
The crux of the question, simple as it may be, is both the "what", and the "we". Obviously by "we" I assume you mean yourself in the context of a philosophical or moral dilemma. If by "we" you mean society as a whole, that'll have to wait for another day, and truthfully, you really shouldn't be concerned with the actions of others beyond the limits that they affect you personally. Aurelius explains it simply in Meditations: "You have power over your mind - not outside events. Realize this, and you will find strength." Once we've settled on the subject in question of the issue at hand, it's time to delve into that second part of the equation, the "what". For the purposes of this response I'll assume you mean the course of action your life takes, the ebbs and flows of your consciousness impacting and altering the physical world around you, from birth to the moment of your death (you'll have to bear with me on assumptions, the prompt wasn't very clear).
Starting with the moment of birth you can of course ascribe to either the monotheist platform of organized religion, or the less religious ideas of worldly philosophers such as Plato or Aristotle. If we're going down the religious school of thought, I'll stick with Aquinas. He's universally recognized as one of the most influential philosophers in Catholicism and, more importantly, most of the time he spits it better than 90% of the frock wearing flock. Aquinas keeps it simple: "There must be must be a first mover existing above all – and this we call God." He believed that unity and oneness with God would equate to happiness and should be the desire of every man. By pursuing this oneness, he argued, man would better himself. If you're a man of faith, the conversation pretty much begins and ends with that. For it is hard to argue against the pursuit of unity with God if you are a true believer in that God.
If, on the other hand, you're more inclined to believe those who would shrug off organized religion as a circus sans tent, Plato is likely to be of interest to you. The central idea of The Republic is that good in itself is its own reward. It is the solution to which the entire dialogue has been building towards, and its revelation completes a puzzle masterfully crafted through Socratic dialogue. If this is enough for you, as it was for me, go out and do good, and you'll find that Plato was onto something here. As to your question, perhaps Plato would have answered it similar to the way he answered another posed to him: "Nothing beautiful without struggle." The goal of your life, whatever that may be, should naturally be beautiful, as we likely only have one chance to create a lasting impact on this world. Therefore, it stands to reason that struggle and the pursuit of success and beauty in life should form the main basis of your "what". Figure out a goal and then struggle to pursue it to the best of your ability, to make it as perfect and beautiful as you can.
Well, that's my take on the subject. Hope it helps.
